Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4)-Reference-Cited by-同舟云学术

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Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4)

Published:2017 Issue:36 Volume:15 Page:7623-7629
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Frasinyuk Mykhaylo S.¹²³⁴⁵,Zhang Wen¹²³⁴⁵,Wyrebek Przemyslaw¹²³⁴⁵,Yu Tianxin¹²³⁴⁵,Xu Xuehe¹²³⁴⁵,Sviripa Vitaliy M.⁶⁷³⁴⁵^ORCID,Bondarenko Svitlana P.⁸⁹¹⁰,Xie Yanqi¹²³⁴⁵,Ngo Huy X.¹¹⁷³⁴⁵,Morris Andrew J.¹²²³⁴⁵,Mohler James L.¹³¹⁴¹⁵⁵,Fiandalo Michael V.¹³¹⁴¹⁵⁵,Watt David S.¹²³⁴⁵,Liu Chunming¹²³⁴⁵^ORCID

Affiliation:

1. Department of Molecular and Cellular Biochemistry

2. College of Medicine

3. University of Kentucky

4. Lexington

5. USA

6. Center for Pharmaceutical Research and Innovation

7. College of Pharmacy

8. National University of Food Technologies

9. Kyiv

10. Ukraine

11. Department of Pharmaceutical Sciences

12. Department of Pharmacology and Nutritional Sciences

13. Department of Urology

14. Roswell Park Cancer Institute

15. Buffalo

Abstract

Cytisine-linked isoflavonoids (CLIFs) inhibit cancer cells by targeting the peroxisomal enzyme HSD17B4.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01584D

Reference25 articles.

1. Antineoplastic Isoflavonoids Derived from Intermediateortho-Quinone Methides Generated from Mannich Bases

2. Application of Mannich bases to the synthesis of hydroxymethylated isoflavonoids as potential antineoplastic agents

3. The promise and peril of chemical probes

4. Isoflavones—Safe food additives or dangerous drugs?

5. Western diet and Western diseases: Some hormonal and biochemical mechanisms and associations

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