Application of Mannich bases to the synthesis of hydroxymethylated isoflavonoids as potential antineoplastic agents-Reference-Cited by-同舟云学术

Application of Mannich bases to the synthesis of hydroxymethylated isoflavonoids as potential antineoplastic agents

Published:2015 Issue:46 Volume:13 Page:11292-11301
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Frasinyuk Mykhaylo S.¹²³⁴⁵,Mrug Galyna P.¹²³⁴,Bondarenko Svitlana P.⁶⁷⁴,Sviripa Vitaliy M.⁵⁸⁹¹⁰¹¹,Zhang Wen⁵⁸⁹¹⁰¹¹,Cai Xianfeng⁵⁸⁹¹⁰¹¹,Fiandalo Michael V.¹²¹³¹⁴¹⁵¹¹,Mohler James L.¹²¹³¹⁴¹⁵¹¹,Liu Chunming⁵⁸⁹¹⁰¹¹,Watt David S.⁵⁸⁹¹⁰¹¹

Affiliation:

1. Institute of Bioorganic Chemistry and Petrochemistry

2. National Academy of Science of Ukraine

3. Kyiv 02094

4. Ukraine

5. Department of Molecular and Cellular Biochemistry

6. Taras Shevchenko Kyiv National University

7. Kyiv 01601

8. College of Medicine

9. University of Kentucky

10. Lexington

11. USA

12. Department of Urology

13. Elm & Carlton Streets

14. Roswell Park Cancer Institute

15. Buffalo

Abstract

C-6 and C-8 Hydroxy-, acetoxy- and alkoxymethyl derivatives of isoflavones were synthesized from Mannich bases and show inhibition in the low micromolar range in a prostate cancer PC3 cell line.

Funder

National Institutes of Health

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01828E

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1. Soy Isoflavones: a Safety Review

2. Western diet and Western diseases: Some hormonal and biochemical mechanisms and associations