A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity-Reference-Cited by-同舟云学术

A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity

Published:2016 Issue:6 Volume:14 Page:2015-2024
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Palomba M.¹²³⁴,Rossi L.¹²³⁴,Sancineto L.¹²³⁴,Tramontano E.⁵⁶⁷⁴,Corona A.⁵⁶⁷⁴,Bagnoli L.¹²³⁴,Santi C.¹²³⁴,Pannecouque C.⁸⁹¹⁰¹¹¹²,Tabarrini O.¹²³⁴,Marini F.¹²³⁴

Affiliation:

1. Dipartimento di Scienze Farmaceutiche

2. Università degli Studi di Perugia

3. 06123 Perugia

4. Italy

5. Dipartimento di Scienze della Vita e dell'Ambiente

6. Cittadella Universitaria di Monserrato SS554 – 09042

7. Monserrato (Cagliari)

8. KU Leuven

9. Department of Microbiology and Immunology

10. Laboratory of Virology and Chemotherapy

11. Rega Institute for Medical Research

12. B-3000 Leuven

Abstract

A flexible synthesis of spirocyclopropyl oxindoles from vinyl selenones and oxindoles via a domino Michael addition/proton transfer/cyclization sequence has been developed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02451J

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5. The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents

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