Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as novel HIV-1 integrase strand transfer inhibitors-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as novel HIV-1 integrase strand transfer inhibitors

Published:2024 Issue:13 Volume:14 Page:9020-9031
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhang Rong-Hong¹²,Chen Guo-Qi¹³,Wang Weilin⁴,Wang Yu-Chan³,Zhang Wen-Li³,Chen Ting³,Xiong Qian-Qian³,Zhao Yong-Long³,Liao Shang-Gao³,Li Yong-Jun¹,Yan Guo-Yi⁵,Zhou Meng¹³^ORCID

Affiliation:

1. State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang, 550004, P. R. China

2. Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Regenerative Medicine of Guizhou Province, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, 550004, P. R. China

3. School of Pharmacy, Guizhou Medical University, Guian New District, Guizhou, 550025, P. R. China

4. State Key Laboratory of Biotherapy, Collaborative Innovation of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China

5. School of Pharmacy, Xinxiang University, Xinxiang, 453000, P. R. China

Abstract

Integrase plays an important role in the life cycle of HIV-1, and indole-2-carboxylic acid derivative 17a can effectively inhibit the strand transfer of integrase.

Funder

Guizhou Provincial Science and Technology Department

Guizhou Medical University

Department of Education of Guizhou Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA08320A

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