<i>p</i>-Toluenesulfonic acid-catalyzed regioselective C4–H iodination of isoquinolin-1(2<i>H</i>)-ones-Reference-Cited by-同舟云学术

p-Toluenesulfonic acid-catalyzed regioselective C4–H iodination of isoquinolin-1(2H)-ones

Published:2022 Issue:22 Volume:46 Page:10934-10939
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Yang Cai-Yun¹,Hu Lin-Ping¹,Zhang De-Run¹,Li Xia²,Teng Ming-Yu¹,Liu Bo¹,Huang Guo-Li¹^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650500, China

2. Department of Library, Yunnan Normal University, Kunming, 650500, China

Abstract

An efficient procedure for p-toluenesulfonic acid-catalyzed iodination of isoquinolin-1(2H)-ones with N-iodosuccinimide under mild reaction conditions is reported. This methodology features scalable synthesis, wide substrate scope, and high functional-group tolerance.

Funder

National Natural Science Foundation of China

Yunnan Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ00159D

Reference35 articles.

1. 5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)

2. Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases