Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases-Reference-Cited by-同舟云学术

Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

Published:2014-02-10 Issue:4 Volume:57 Page:1299-1322
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kaila Neelu¹,Follows Bruce¹,Leung Louis¹,Thomason Jennifer¹,Huang Adrian¹,Moretto Alessandro¹,Janz Kristin¹,Lowe Michael¹,Mansour Tarek S.¹,Hubeau Cedric¹,Page Karen¹,Morgan Paul¹,Fish Susan¹,Xu Xin¹,Williams Cara¹,Saiah Eddine¹

Affiliation:

1. Pfizer Research and Development, Cambridge, Massachusetts 02140, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401509e

Reference27 articles.

1. Advances in eicosanoid research, novel therapeutic implications

2. Mast Cells and Arachidonic Acid Cascade in Inflammation

3. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)