Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases
Author:
Affiliation:
1. Pfizer Research and Development, Cambridge, Massachusetts 02140, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm401509e
Reference27 articles.
1. Advances in eicosanoid research, novel therapeutic implications
2. Mast Cells and Arachidonic Acid Cascade in Inflammation
3. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)
4. The second PGD2 receptor CRTH2: structure, properties, and functions in leukocytes
5. Emerging roles of DP and CRTH2 in allergic inflammation
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