Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836-Reference-Cited by-同舟云学术

Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836

Published:2024-09-04 Issue: Volume: Page:
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cole Andrew G.¹^ORCID,Kultgen Steven G.¹^ORCID,Mani Nagraj¹,Fan Kristi Yi¹^ORCID,Ardzinski Andrzej¹,Stever Kim¹,Dorsey Bruce D.¹,Mesaros Eugen F.¹^ORCID,Thi Emily P.¹^ORCID,Graves Ingrid¹^ORCID,Tang Sunny¹,Harasym Troy O.¹,Lee Amy C. H.¹^ORCID,Olland Andrea²,Suto Robert K.²^ORCID,Sofia Michael J.¹

Affiliation:

1. Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, Pennsylvania 18974, United States

2. Xtal BioStructures Inc., 12 Michigan Drive, Natick, Massachusetts 01760, United States

Funder

Arbutus Biopharma, Inc.

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01568

Reference35 articles.

1. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b July 2023.

2. Current treatments for chronic hepatitis B virus infections

3. New Therapeutics for Hepatitis B: The Road to Cure

4. Hepatitis B: Reflections on the current approach to antiviral therapy

5. Hepatitis B Virus Entry into Cells

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1. Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators;ACS Medicinal Chemistry Letters;2024-09-03