Mast Cells and Arachidonic Acid Cascade in Inflammation-Reference-Cited by-同舟云学术

Mast Cells and Arachidonic Acid Cascade in Inflammation

Published:2009-09 Issue:3 Volume:7 Page:131-137
ISSN:2058-7392
Container-title:European Journal of Inflammation
language:en
Short-container-title:Eur J Inflamm

Author:

Castellani M.L.¹,Felaco M.²,Pandolfi F.³,Salini V.⁴,De Amicis D.⁴,Orso C.⁴,Vecchiet J.⁵,Tetè S.⁶,Ciampoli C.⁶,Conti F.⁷,Cerulli G.⁸,Caraffa A.⁸,Antinolfi P.⁸,Cuccurullo C.⁹,Felaco P.¹⁰,Kempuraj D.¹¹,Boscolo P.¹²,Sabatino G.¹³,Shaik Y.B.¹⁴

Affiliation:

1. Immunology Division, Medical School, University of Chieti-Pescara, Italy

2. Division of Biology, University of Chieti, Italy

3. Catholic University, Rome, Italy

4. Department of Human Dynamics, University of Chieti-Pescara, Italy

5. Clinic of Infectious Diseases, Medical School, University of Chieti-Pescara, Italy

6. Dental School, University of Chieti-Pescara, Italy

7. Gynecology Division, University of Chieti, Italy

8. Orthopeadics Division, University of Perugia, Italy

9. Division of Medical Pathology, University of Chieti

10. Nephrology Division, University of Chieti, Chieti, Italy

11. Department of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine Tufts University School of Medicine, Tufts-New England Medical Center, Boston, MA, USA

12. Department of Biomedical Science, University of Chieti, Chieti, Italy

13. Department of Paediatrics, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy

14. Department of Medicine, Boston University School of Medicine, Boston, MA, USA

Abstract

Prostaglandin D2 PGD2 is a major cyclooxygenase metabolite of arachidonic acid produced by mast cells and it is released following allergen challenge in diseases, such as allergic diseases. PGD2 may act as a neuromodulator and as an allergic and inflammatory mediator. In allergic diseases, activated mast cell synthesizes prostaglandin D2 (first cyclo-oxygenate mediator) which has bronchoconstrictive and vasodilating effects and attracts several leukocytes. It has been found that activated mast cells, challenged with physiological and non- physiological secretagogues, release elevated histamine and tryptase and chymase, leukotrienes B4, C4 and D4, 5-hydroxyeicosatetraenoic acid, PGD2, Platelet Activating Factor (PAF), heparin, and high-molecular-weight neutrophil chemotactic factor and cytokines/chemokines. PGD2 exerts its biological activity through the DP and CRTH2 receptors and their cDNA cloning which were characterized 15 years ago. In this report, we revisited the biological effects of arachidonic acid compounds released by activated mast cells in allergic and inflammatory states.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/1721727X0900700302

Reference62 articles.

1. CCL16 Enhances the CD8+ and CD4+ T Cell Reactivity to Human Her-2 Elicited by Dendritic Cells Loaded with Rat Ortholog Her-2

2. Recombinant Allergens Promote Expression of Aminopeptidase-N (CD13) on Basophils in Allergic Patients

3. CD203c is Overexpressed on Neoplastic Mast Cells in Systemic Mastocytosis and is Upregulated upon IgE Receptor Cross-Linking

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