Diazine Indole Acetic Acids as Potent, Selective, and Orally Bioavailable Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases-Reference-Cited by-同舟云学术

Diazine Indole Acetic Acids as Potent, Selective, and Orally Bioavailable Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

Published:2012-05-31 Issue:11 Volume:55 Page:5088-5109
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kaila Neelu¹,Huang Adrian¹,Moretto Alessandro¹,Follows Bruce¹,Janz Kristin¹,Lowe Michael¹,Thomason Jennifer¹,Mansour Tarek S.¹,Hubeau Cedric¹,Page Karen¹,Morgan Paul¹,Fish Susan¹,Xu Xin¹,Williams Cara¹,Saiah Eddine¹

Affiliation:

1. BioTherapeutics Chemistry, Pfizer Worldwide Medicinal Chemistry, 200 Cambridgepark Drive, Cambridge, Massachusetts 02140, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300007n

Reference49 articles.

1. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)

2. The second PGD2 receptor CRTH2: structure, properties, and functions in leukocytes

3. Emerging roles of DP and CRTH2 in allergic inflammation