5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)-Reference-Cited by-同舟云学术

5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)

Published:2011-03-18 Issue:7 Volume:54 Page:2049-2059
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sunderland Peter T.¹,Woon Esther C. Y.¹,Dhami Archana¹,Bergin Aoife B.¹,Mahon Mary F.²,Wood Pauline J.¹,Jones Louise A.³,Tully Sophie R.³,Lloyd Matthew D.¹,Thompson Andrew S.¹,Javaid Hashim³,Martin Niall M. B.³,Threadgill Michael D.¹

Affiliation:

1. Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, U.K.

2. Crystallography Unit, Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K.

3. KuDOS Pharmaceuticals Ltd., 410 Cambridge Science Park, Milton Road, Cambridge CB4 0PE, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1010918

Reference63 articles.

1. Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

2. PARP inhibition: PARP1 and beyond

3. Poly(ADP-ribose)polymerase Inhibition - Where Now?

4. The world according to PARP

5. Poly(ADP-ribose) polymerase: a molecular nick-sensor

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