Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor-Reference-Cited by-同舟云学术

Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor

Published:2018 Issue:4 Volume:8 Page:2219-2228
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Boyhus Lotte-Emilie¹²³⁴,Danielsen Mia¹²³⁴^ORCID,Bengtson Nina Smidt¹²³⁴,Ben Achim Kunze Micha⁵⁶²⁷⁴,Kubiak Xavier⁸²⁷⁴,Sminia Tjerk J.¹²³⁴,Løper Jacob Hartvig¹²³⁴,Tran Phuong Thu¹²³⁴,Lindorff-Larsen Kresten⁵⁶²⁷⁴^ORCID,Rasmussen Søren G. F.⁸²⁷⁴,Mathiesen Jesper Mosolff¹²³⁴,Pedersen Daniel Sejer¹²³⁴^ORCID

Affiliation:

1. Department of Drug Design and Pharmacology

2. University of Copenhagen

3. 2100 Copenhagen

4. Denmark

5. Structural Biology and NMR Laboratory

6. Department of Biology

7. 2200 Copenhagen

8. Department of Neuroscience

Abstract

A series of G_s protein peptidomimetics were designed and synthesised based on the published X-ray crystal structure of the active state β₂-adrenergic receptor (β₂AR) in complex with the G_s protein (PDB 3SN6).

Funder

Lundbeckfonden

Carlsbergfondet

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C7RA11713B

Reference31 articles.

1. How many drug targets are there?

2. Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry