The protective effect of hydroxytyrosol acetate against inflammation of vascular endothelial cells partly through the SIRT6-mediated PKM2 signaling pathway-Reference-Cited by-同舟云学术

The protective effect of hydroxytyrosol acetate against inflammation of vascular endothelial cells partly through the SIRT6-mediated PKM2 signaling pathway

Published:2019 Issue:9 Volume:10 Page:5789-5803
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Yao Feng¹²³⁴,Yang Guangde⁵²³⁴,Xian Yushan¹²³⁴,Wang Guan¹²³⁴,Zheng Zihan¹²³⁴,Jin Zhen¹²³⁴,Xie Yundong⁶⁷⁸⁴,Wang Weirong⁹²³⁴,Gu Jianli²³⁴¹⁰¹¹,Lin Rong¹²³⁴^ORCID

Affiliation:

1. Department of Pharmacology

2. Xi'an Jiaotong University Health Science Center

3. Xi'an 710061

4. China

5. School of Pharmacy

6. College of Pharmacy

7. Shaanxi University of Chinese Medicine

8. Xianyang 712000

9. Department of Medical Experiment Animal Science

10. Xi'an NO.3 hospital

11. Xi'an 710018

Abstract

HT-AC had anti-inflammatory effect in hypercholesterolemic mice and TNF-stimulated HUVECs. HT-AC inhibited the inflammatory response partly through the TNFRSF1A/SIRT6/PKM2-mediated signaling pathway.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/FO/C9FO00586B

Reference37 articles.

1. Effect on Insulin, Glucose and Lipids in Overweight/Obese Australian Adults of 12 Months Consumption of Two Different Fibre Supplements in a Randomised Trial

2. Distribution of Hydroxytyrosol and Hydroxytyrosol Acetate in Olive Oil Emulsions and Their Antioxidant Efficiency

3. Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through the SIRT1-mediated signaling pathway