Synthetic α-hydroxytropolones as inhibitors of HIV reverse transcriptase ribonuclease H activity-Reference-Cited by-同舟云学术

Synthetic α-hydroxytropolones as inhibitors of HIV reverse transcriptase ribonuclease H activity

Published:2016 Issue:9 Volume:7 Page:1783-1788
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Murelli Ryan P.¹²³⁴⁵,D'Erasmo Michael P.¹²³⁴⁵,Hirsch Danielle R.¹²³⁴⁵,Meck Christine¹²³⁴⁵,Masaoka Takashi⁶⁷⁸⁹⁵,Wilson Jennifer A.¹⁰⁷⁸⁹⁵,Zhang Baofeng¹²³⁴⁵,Pal Rajat K.¹²³⁴⁵,Gallicchio Emilio¹²³⁴⁵,Beutler John A.¹⁰⁷⁸⁹⁵,Le Grice Stuart F. J.⁶⁷⁸⁹⁵

Affiliation:

1. Department of Chemistry

2. Brooklyn College

3. The City University of New York

4. New York

5. USA

6. Basic Research Laboratory

7. Center for Cancer Research

8. National Cancer Institute at Frederick

9. Frederick

10. Molecular Targets Laboratory

Abstract

HIV reverse transcriptase-associated ribonuclease H activity is a promising enzymatic target for drug development. The following describes the activity of synthetic α-hydroxytropolones in HIV ribonuclease H-associated assays.

Funder

National Science Foundation

National Institutes of Health

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00238B

Reference33 articles.

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2. Recent Progress in the Research of Small Molecule HIV-1 RNase H Inhibitors

3. HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition

4. Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold

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