Synthetic α-hydroxytropolones as inhibitors of HIV reverse transcriptase ribonuclease H activity
Author:
Affiliation:
1. Department of Chemistry
2. Brooklyn College
3. The City University of New York
4. New York
5. USA
6. Basic Research Laboratory
7. Center for Cancer Research
8. National Cancer Institute at Frederick
9. Frederick
10. Molecular Targets Laboratory
Abstract
HIV reverse transcriptase-associated ribonuclease H activity is a promising enzymatic target for drug development. The following describes the activity of synthetic α-hydroxytropolones in HIV ribonuclease H-associated assays.
Funder
National Science Foundation
National Institutes of Health
Division of Intramural Research, National Institute of Allergy and Infectious Diseases
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00238B
Reference33 articles.
1. Human Immunodeficiency Virus Reverse Transcriptase: A Bench to Bedside Success, ed. S. Le Grice and M. Gotte, Springer, New York, 2013
2. Recent Progress in the Research of Small Molecule HIV-1 RNase H Inhibitors
3. HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition
4. Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold
Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Recent advances on dual inhibitors targeting HIV reverse transcriptase associated polymerase and ribonuclease H;European Journal of Medicinal Chemistry;2023-03
2. Troponoid Compounds as Therapeutic Agents and as Targets and Templates for Chemical Synthesis;Synlett;2022-08-16
3. Synthesis of Polyoxygenated Tropolones and their Antiviral Activity against Hepatitis B Virus and Herpes Simplex Virus‐1;Chemistry – A European Journal;2022-01-31
4. Effects of Troponoids on Mitochondrial Function and Cytotoxicity;Antimicrobial Agents and Chemotherapy;2022-01-18
5. Pyrans and Their Benzo Derivatives: Structure and Reactivity;Comprehensive Heterocyclic Chemistry IV;2022
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3