Effects of Troponoids on Mitochondrial Function and Cytotoxicity-Reference-Cited by-同舟云学术

Effects of Troponoids on Mitochondrial Function and Cytotoxicity

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bradley Daniel P.¹²,O’Dea Austin T.¹,Woodson Molly E.¹²,Li Qilan¹²,Ponzar Nathan L.¹²,Knier Alaina¹²,Rogers Bruce L.³,Murelli Ryan P.⁴⁵,Tavis John E.¹²^ORCID

Affiliation:

1. Saint Louis University School of Medicine, St. Louis, Missouri, USA

2. Saint Louis University Institute for Drug and Biotherapeutic Innovation, St. Louis, Missouri, USA

3. Casterbridge Pharmaceuticals, Woburn, Massachusetts, USA

4. Brooklyn College, City University of New York, New York, New York, USA

5. Ph.D. Program in Chemistry, The Graduate Center of The City University of New York, New York, New York, USA

Abstract

The α-hydroxytropolones (αHTs) are troponoid inhibitors of hepatitis B virus (HBV) replication that can target HBV RNase H with submicromolar efficacies. αHTs and related troponoids (tropones and tropolones) can be cytotoxic in cell lines as measured by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2 H -tetrazolium (MTS) assays that assess mitochondrial function. Previous studies suggest that tropolones induce cytotoxicity through inhibition of mitochondrial respiration.

Funder

HHS | National Institutes of Health

Small Business Innovation Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01617-21

Reference48 articles.

1. Tropones and Tropolones

2. Synthesis and Evaluation of Troponoids as a New Class of Antibiotics

3. Troponoids Can Inhibit Growth of the Human Fungal Pathogen Cryptococcus neoformans

4. β-Thujaplicinol inhibits hepatitis B virus replication by blocking the viral ribonuclease H activity

5. Synthetic α-hydroxytropolones as inhibitors of HIV reverse transcriptase ribonuclease H activity

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