HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition-Reference-Cited by-同舟云学术

HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition

Published:2009-05 Issue:3 Volume:388 Page:462-474
ISSN:0022-2836
Container-title:Journal of Molecular Biology
language:en
Short-container-title:Journal of Molecular Biology

Author:

Beilhartz Greg L.,Wendeler Michaela,Baichoo Noel,Rausch Jason,Le Grice Stuart,Götte Matthias

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference49 articles.

1. Retroviruses;Telesnitsky,1997

2. Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase;Davies;Science,1991

3. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA;Jacobo-Molina;Proc. Natl Acad. Sci. USA,1993

4. Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA;Sarafianos;EMBO J.,2001

5. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance;Huang;Science,1998

Cited by 56 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities;Biomolecules;2024-07-09

2. Charge Engineering of the Nucleic Acid Binding Cleft of a Thermostable HIV-1 Reverse Transcriptase Reveals Key Interactions and a Novel Mechanism of RNase H Inactivation;Journal of Molecular Biology;2023-09

3. Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition;Proceedings of the National Academy of Sciences;2022-06-30

4. Novel RNase H Inhibitors Blocking RNA-directed Strand Displacement DNA Synthesis by HIV-1 Reverse Transcriptase;Journal of Molecular Biology;2022-04

5. The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor;Journal of Biological Chemistry;2021-01