Troponoid Compounds as Therapeutic Agents and as Targets and Templates for Chemical Synthesis

Abstract

AbstractThe renewed interest in troponoid compounds as potential therapeutic agents and the ongoing discovery of new, naturally occurring and biologically active members of the class has resulted in an attendant focus on developing and deploying methods for their synthesis. This account highlights some of the significant recent developments in the area of troponoid chemistry that serve to contextualize our group’s longstanding and ongoing interest in the synthesis of such compounds through the cyclopropane-mediated ring-expansion of cyclohexanoid and benzenoid compounds. The various means by which such conversions can be accomplished and their application to the synthesis of both natural and non-natural troponoids are detailed.1 Introduction2 Naturally Occurring Troponoid Compounds and Their Biogenesis3 Medicinal Chemistry Aspects of Troponoid Compounds4 Troponoids in Materials Science5 Troponoids as Scaffolds in Chemical Synthesis6 An Overview of the Methods Available for Preparing Troponoids7 Cyclopropane-Mediated Ring-Expansion Reactions Leading to Troponoids8 Conclusions