Recent developments in the synthesis of the isoquinoline-1,3(2<i>H</i>,4<i>H</i>)-dione by radical cascade reaction-Reference-Cited by-同舟云学术

Recent developments in the synthesis of the isoquinoline-1,3(2H,4H)-dione by radical cascade reaction

Published:2022 Issue:40 Volume:20 Page:7861-7885
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Niu Yan-Ning¹^ORCID,Xia Xiao-Feng²^ORCID

Affiliation:

1. Department of Teaching and Research, Nanjing Forestry University, Huaian, Jiangsu, 223003, People's Republic of China

2. Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu, 214122, People's Republic of China

Abstract

The synthesis of isoquinoline-1,3(2H,4H)-diones via radical cascade reaction from acryloyl benzamides is reviewed according to different radical precursors, such as that containing carbon, sulphur, phosphorus, nitrogen, bromine and silicon.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01554D

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1. Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2H,4H)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function

2. Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

3. Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton