Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2H,4H)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function-Reference-Cited by-同舟云学术

Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2H,4H)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function

Published:2011-03-02 Issue:6 Volume:54 Page:1812-1824
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Billamboz Muriel¹²,Bailly Fabrice¹²,Lion Cédric¹²,Touati Nadia¹³,Vezin Hervé¹³,Calmels Christina⁴,Andréola Marie-Line⁴,Christ Frauke⁵,Debyser Zeger⁵,Cotelle Philippe¹²

Affiliation:

1. Université Lille Nord de France, F-59000 Lille, France

2. USTL, EA 4478 Chimie moléculaire et formulation, F-59650 Villeneuve d'Ascq, France

3. USTL, UMR CNRS 8516, F-59650 Villeneuve d'Ascq, France

4. Institut Fédératif de Recherches “Pathologies Infectieuses et Cancers” (IFR 66), MCMP-UMR 5234 CNRS, Université Victor Segalen Bordeaux 2, F-33076 Bordeaux, France

5. Molecular Medicine, K. U. Leuven and IRC KULAK, Kapucijnenvoer 33, B-3000 Leuven, Flanders, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1014692

Reference61 articles.

1. The design of drugs for HIV and HCV

3. RNase H activity: Structure, specificity, and function in reverse transcription

4. Structure and Function of HIV-1 Integrase

5. Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold

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