Regioselective synthesis of isoquinolinonediones through remote unactivated C(sp<sup>3</sup>)

Regioselective synthesis of isoquinolinonediones through remote unactivated C(sp³)–H bonds

Published:2024 Issue:36 Volume:60 Page:4818-4821
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Huang Lei¹,Sun Jun¹,Sun Boxuan¹,Song Shengjie¹,Li Jianjun¹²³^ORCID

Affiliation:

1. Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China

2. Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China

3. Taizhou Key Laboratory of Advanced Manufacturing Technology, Taizhou Institute, Zhejiang University of Technology, Taizhou 318014, P. R. China

Abstract

A novel remote-site-selective cascade addition/cyclization protocol for free alcohols and sulfonamides to build in one step isoquinolinonedione skeletons without pre-activation was developed.

Funder

National Natural Science Foundation of China

Science and Technology Plan Project of Taizhou

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC00916A

Reference48 articles.

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2. Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2H,4H)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function

3. 4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors

4. Tandem radical cyclization of N-methacryloyl benzamides with CBr4 to construct brominated isoquinolinediones

5. Difunctionalization of Alkenes via the Visible-Light-Induced Trifluoromethylarylation/1,4-Aryl Shift/Desulfonylation Cascade Reactions

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