Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay-Reference-Cited by-同舟云学术

Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay

Published:2015 Issue:33 Volume:5 Page:25768-25776
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wang Jixia¹²³⁴⁵,Hou Tao⁶⁷⁴⁵,Wei Lai¹²³⁴⁵,Shi Liying⁶⁷⁴⁵,He Jian¹²³⁴⁵,Zhou Nan⁸⁹¹⁰⁴⁵,Sun Guangwei¹²³⁴⁵,Zhang Xiuli¹²³⁴⁵,Liang Xinmiao¹²³⁴⁵

Affiliation:

1. Key Lab of Separation Science for Analytical Chemistry

2. Dalian Institute of Chemical Physics

3. Chinese Academy of Sciences

4. Dalian

5. China

6. Institute of Materia Medica

7. Dalian University

8. Department of Oral Pathology

9. College of Stomatology

10. Dalian Medical University

Abstract

Pharmacological profiling of 10 known phenolic acids in danshen using a label-free cell phenotypic assay in HT-29 and A431 cells revealed that lithospermic acid, salvianolic acid A, B, C and danshensu all displayed agonistic activity towards GPR35.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA16102E

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