Accelerating reaction modeling using dynamic flow experiments, part 2: development of a digital twin-Reference-Cited by-同舟云学术

Accelerating reaction modeling using dynamic flow experiments, part 2: development of a digital twin

Published:2023 Issue:11 Volume:8 Page:2849-2855
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Silber Klara¹²^ORCID,Sagmeister Peter¹²^ORCID,Schiller Christine¹²^ORCID,Williams Jason D.¹²^ORCID,Hone Christopher A.¹²^ORCID,Kappe C. Oliver¹²^ORCID

Affiliation:

1. Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

2. Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria

Abstract

We describe the development of a digital twin for a Michael addition continuous-flow process using data generated from dynamic flow experimentation.

Funder

Steirische Wirtschaftsför-derungsgesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D3RE00244F

Reference30 articles.

1. Pharmaceutical Process Chemistry: Evolution of a Contemporary Data-Rich Laboratory Environment

2. Modernizing Pharmaceutical Manufacturing: from Batch to Continuous Production

3. Digital methods and tools for chemical equipment and plants

4. Digital Twins in Pharmaceutical and Biopharmaceutical Manufacturing: A Literature Review

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