Kinetic Study and Model-Based Design Space Determination for a Drug Substance Flow Synthesis Using an Amination Reaction via Nucleophilic Aromatic Substitution-Reference-Cited by-同舟云学术

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Kinetic Study and Model-Based Design Space Determination for a Drug Substance Flow Synthesis Using an Amination Reaction via Nucleophilic Aromatic Substitution

Published:2024-04-04 Issue:5 Volume:28 Page:1793-1805
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Kim Junu¹^ORCID,Hayashi Yusuke¹^ORCID,Badr Sara¹^ORCID,Okamoto Kazuya²,Hakogi Toshikazu²,Furukawa Haruo²,Yoshikawa Satoshi³,Nakanishi Hayao³,Sugiyama Hirokazu¹^ORCID

Affiliation:

1. Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

2. Technology Development Department, Pharmira Co., Ltd., 2-1-3 Kuise Terajima, Amagasaki, Hyogo 660-0813, Japan

3. Production Technology Department, Shionogi Pharma Co., Ltd., 2-1-3 Kuise Terajima, Amagasaki, Hyogo 660-0813, Japan

Funder

Shionogi Pharma Co., Ltd

Pharmira Co., Ltd.

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00380

Reference41 articles.

1. Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

2. The Continuous-Flow Synthesis of Ibuprofen

3. A Three-Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous-Flow Processing

4. A Concise Flow Synthesis of Efavirenz

5. Rapid On-Demand Synthesis of Lomustine under Continuous Flow Conditions

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