Pyridylic anions are soft nucleophiles in the palladium-catalyzed C(sp3)–H allylation of 4-alkylpyridines-Reference-Cited by-同舟云学术

Pyridylic anions are soft nucleophiles in the palladium-catalyzed C(sp3)–H allylation of 4-alkylpyridines

Published:2021 Issue:4 Volume:12 Page:1503-1512
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wasfy Nour¹²³⁴,Rasheed Faizan¹²³⁴,Robidas Raphaël¹⁵⁶⁷⁴^ORCID,Hunter Isabelle¹²³⁴,Shi Jiaqi¹²³⁴,Doan Brian¹²³⁴,Legault Claude Y.¹⁵⁶⁷⁴,Fishlock Dan⁸⁹¹⁰¹¹¹²,Orellana Arturo¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. York University

3. Toronto

4. Canada

5. Centre in Green Chemistry and Catalysis

6. University of Sherbrooke

7. Sherbrooke

8. Process Chemistry and Catalysis

9. Synthetic Molecule Technical Development

10. F. Hoffmann-La Roche Ltd

11. 4070 Basel

12. Switzerland

Abstract

We report a mild palladium-catalyzed method for the selective allylation of 4-alkylpyridines in which highly basic pyridylic anions behave as soft nucleophiles.

Funder

Roche

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC03304A

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1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Rings in Drugs