Stability and reactivity of alkylidene dihydropyridines-Reference-Cited by-同舟云学术

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Stability and reactivity of alkylidene dihydropyridines

Published:2024 Issue:20 Volume:22 Page:4052-4056
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Puzhistky Matthew¹,Pradhan Ekadashi¹,Nikolaev Andrei¹^ORCID,Zeng Tao¹^ORCID,Fishlock Dan²,Orellana Arturo¹^ORCID

Affiliation:

1. Department of Chemistry, York University, Toronto, ON, M3J 1P3, Canada

2. Roche Pharma Research and Early Development, pCMC Drug Substance, Roche Innovation Center Basel, F. Hoffmann – La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland

Abstract

We study the effect of pyridine and chloroformate structure on the stability and reactivity of alkylidene dihydropyridines using NMR trends, measured and calculated oxidation potentials, and decomposition studies.

Funder

F. Hoffmann-La Roche

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00200H

Reference24 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Rings in Drugs

3. Pyridylic anions are soft nucleophiles in the palladium-catalyzed C(sp3)–H allylation of 4-alkylpyridines

4. Palladium-Catalyzed, Mild Dehydrogenation of 4-Alkylpyridines

5. Mild Installation of Piperidines on 4-Alkylpyridines

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