Theoretical and experimental investigation of the polyeletrophilic β-enamino diketone: straightforward and highly regioselective synthesis of 1,4,5-trisubstituted pyrazoles and pyrazolo[3,4-d]pyridazinones-Reference-Cited by-同舟云学术

Theoretical and experimental investigation of the polyeletrophilic β-enamino diketone: straightforward and highly regioselective synthesis of 1,4,5-trisubstituted pyrazoles and pyrazolo[3,4-d]pyridazinones

Published:2016 Issue:1 Volume:6 Page:290-302
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

da Silva Michael J. V.¹²³⁴⁵,Silva Raí G. M.¹²³⁴⁵,Melo Ulisses Z.¹²³⁴⁵,Gonçalves Davana S.¹²³⁴⁵,Back Davi F.²⁶⁷⁵,Moura Sidnei⁸⁹¹⁰¹¹⁵,Pontes Rodrigo M.¹²³⁴⁵,Basso Ernani A.¹²³⁴⁵,Gauze Gisele F.¹²³⁴⁵,Rosa Fernanda A.¹²³⁴⁵

Affiliation:

1. Estereoquímica de Compostos Orgânicos e Docking Molecular

2. Departamento de Química

3. Universidade Estadual de Maringá (UEM)

4. Maringá PR

5. Brazil

6. Universidade Federal de Santa Maria (UFSM)

7. 97110-970 – Santa Maria

8. Laboratório de Produtos Naturais e Sintéticos

9. Instituto de Biotecnologia

10. Universidade de Caxias do Sul (UCS)

11. Caxias do Sul

Abstract

A highly efficient regioselective synthesis of 1,4,5-trisubstituted pyrazoles and pyrazolo[3,4-d]pyridazinones from enamino diketone along with a theoretical and experimental study of the chemical reactivity enamino diketone.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA12968K

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2. Guest Editorial

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4. Design and Synthesis of Celecoxib and Rofecoxib Analogues as Selective Cyclooxygenase-2 (COX-2) Inhibitors: Replacement of Sulfonamide and Methylsulfonyl Pharmacophores by an Azido Bioisostere

5. 3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2

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