Discovery of a new pyrido[2,3-<i>d</i>]pyridazine-2,8-dione derivative as a potential anti-inflammatory agent through COX-1/COX-2 dual inhibition-Reference-Cited by-同舟云学术

Discovery of a new pyrido[2,3-d]pyridazine-2,8-dione derivative as a potential anti-inflammatory agent through COX-1/COX-2 dual inhibition

Published:2024 Issue:3 Volume:15 Page:1038-1045
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Rosa Fernanda A.¹^ORCID,Gonçalves Davana S.¹,Pianoski Karlos E.¹,da Silva Michael J. V.¹,Ames Franciele Q.²,Aguiar Rafael P.²,Volpato Hélito³,Lazarin-Bidóia Danielle³,Nakamura Celso V.³,Bersani-Amado Ciomar A.²

Affiliation:

1. Departamento de Química, Universidade Estadual de Maringá (UEM), 87030-900, Maringá, PR, Brazil

2. Departamento de Farmacologia e Terapêutica, Universidade Estadual de Maringá (UEM), 87030-900 Maringá, PR, Brazil

3. Pós-Graduação em Ciências Biológicas, Universidade Estadual de Maringá (UEM), 87020-900 Maringá, PR, Brazil

Abstract

The new pyrido[2,3-d]pyridazine-2,8-dione 7c showed potential anti-inflammatory activity as a COX-1/COX-2 dual inhibitor.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação Araucária

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00604B

Reference20 articles.

1. Anti-inflammatory Effects of Cavidine In Vitro and In Vivo, a Selective COX-2 Inhibitor in LPS-Induced Peritoneal Macrophages of Mouse

2. Anti-inflammatory Activity and Mechanism of Surfactin in Lipopolysaccharide-Activated Macrophages

3. In vitro skin irritation: facts and future. State of the art review of mechanisms and models

4. Non-steroidal anti-inflammatory drugs: recent advances in the use of synthetic COX-2 inhibitors

5. Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs

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