Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway-Reference-Cited by-同舟云学术

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

Published:2019-03-29 Issue:1 Volume:10 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Chang Song Ho,Mori Daisuke,Kobayashi Hiroshi,Mori Yoshifumi,Nakamoto Hideki,Okada Keita,Taniguchi Yuki,Sugita Shurei,Yano Fumiko,Chung Ung-il,Kim-Kaneyama Joo-ri,Yanagita Motoko^ORCID,Economides Aris,Canalis Ernesto,Chen Di,Tanaka Sakae,Saito Taku

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-019-09491-5.pdf

Reference55 articles.

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2. Stanton, H. et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434, 648–652 (2005).

3. Zhu, M. et al. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum. 58, 2053–2064 (2008).

4. Echtermeyer, F. et al. Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat. Med. 15, 1072–1076 (2009).

5. Lin, A. C. et al. Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat. Med. 15, 1421–1425 (2009).

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