Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis-Reference-Cited by-同舟云学术

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

Published:2005-03-31 Issue:7033 Volume:434 Page:644-648
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Glasson Sonya S.,Askew Roger,Sheppard Barbara,Carito Brenda,Blanchet Tracey,Ma Hak-Ling,Flannery Carl R.,Peluso Diane,Kanki Kim,Yang Zhiyong,Majumdar Manas K.,Morris Elisabeth A.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature03369.pdf

Reference16 articles.

1. Sandy, J. D., Flannery, C. R., Neame, P. J. & Lohmander, L. S. The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu373-Ala374 bond of the interglobular domain. J. Clin. Invest. 89, 1512–1516 (1992)

2. Lohmander, L. S., Neame, P. J. & Sandy, J. D. The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. Arthritis Rheum. 36, 1214–1222 (1993)

3. Kuno, K. et al. ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan. FEBS Lett. 478, 241–245 (2000)

4. Rodríquez-Manzaneque, J. C. et al. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochem. Biophys. Res. Commun. 293, 501–508 (2002)

5. Somerville, R. P. T. et al. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J. Biol. Chem. 278, 9503–9513 (2003)

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