Modulating hedgehog signaling can attenuate the severity of osteoarthritis-Reference-Cited by-同舟云学术

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Modulating hedgehog signaling can attenuate the severity of osteoarthritis

Published:2009-11-15 Issue:12 Volume:15 Page:1421-1425
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Lin Alvin C,Seeto Brian L,Bartoszko Justyna M,Khoury Michael A,Whetstone Heather,Ho Louisa,Hsu Claire,Ali S Amanda,Alman Benjamin A

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.2055.pdf

Reference41 articles.

1. Aigner, T., Soder, S., Gebhard, P.M., McAlinden, A. & Haag, J. Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence. Nat. Clin. Pract. Rheumatol. 3, 391–399 (2007).

2. Slagboom, E. & Meulenbelt, I. Genetics of osteoarthritis: early developmental clues to an old disease. Nat. Clin. Pract. Rheumatol. 4, 563 (2008).

3. Mak, K.K., Kronenberg, H.M., Chuang, P.T., Mackem, S. & Yang, Y. Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development 135, 1947–1956 (2008).

4. Maeda, Y. et al. Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc. Natl. Acad. Sci. USA 104, 6382–6387 (2007).

5. Hilton, M.J., Tu, X. & Long, F. Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage. Dev. Biol. 308, 93–105 (2007).

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