Identification of a human multipotent TH2 progenitor
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41590-024-01818-9.pdf
Reference5 articles.
1. Wambre, E. et al. A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders. Sci. Transl. Med. 9, eaam9171 (2017). This paper describes a subset of cytokine-producing effector TH2 cells associated with allergic disease in humans.
2. Upadhyaya, B., Yin, Y., Hill, B. J., Douek, D. C. & Prussin, C. Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells. J. Immunol. 187, 3111–3120 (2011). This work was the first description of a human highly differentiated, cytokine-producing TH2 cell effector subset.
3. Gowthaman, U. et al. Identification of a T follicular helper cell subset that drives anaphylactic IgE. Science 365, eaaw6433 (2019). This paper describes a population of follicular helper T cells that is critical for high-affinity IgE production in allergic disease.
4. Philip, M. & Schietinger, A. CD8+ T cell differentiation and dysfunction in cancer. Nat. Rev. Immunol. 22, 209–223 (2022). This review provides an outstanding overview of the paradigms that have developed to explain the hyporesponsive and stem-like progenitor T cells states observed in cancer.
5. Ma, J. et al. Single-cell analysis pinpoints distinct populations of cytotoxic CD4+ T cells and an IL-10+CD109+ TH2 cell population in nasal polyps. Sci. Immunol. 6, eabg6356 (2021). This study used a single-cell transcriptomic approach to uncover T cell diversity in human nasal polyposis.
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