Identification of a T follicular helper cell subset that drives anaphylactic IgE-Reference-Cited by-同舟云学术

Identification of a T follicular helper cell subset that drives anaphylactic IgE

Published:2019-08-30 Issue:6456 Volume:365 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gowthaman Uthaman¹²^ORCID,Chen Jennifer S.¹²^ORCID,Zhang Biyan¹²^ORCID,Flynn William F.³^ORCID,Lu Yisi²^ORCID,Song Wenzhi²,Joseph Julie¹,Gertie Jake A.¹²^ORCID,Xu Lan¹²^ORCID,Collet Magalie A.³^ORCID,Grassmann Jessica D. S.³^ORCID,Simoneau Tregony⁴^ORCID,Chiang David⁵^ORCID,Berin M. Cecilia⁵^ORCID,Craft Joseph E.²^ORCID,Weinstein Jason S.⁶,Williams Adam³⁷^ORCID,Eisenbarth Stephanie C.¹²^ORCID

Affiliation:

1. Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

2. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

3. The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.

4. The Asthma Center, CT Children's Medical Center, Hartford, CT 06106, USA.

5. Jaffe Food Allergy Institute and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

6. Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07101, USA.

7. The Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT 06032, USA.

Abstract

Thirteen is the charm in anaphylaxis Immunoglobulin E (IgE) is a type of antibody associated with allergies and response to parasites such as worms. When high-affinity, allergen-specific IgE binds its target, it can cross-link receptors on mast cells that induce anaphylaxis. It remains unclear, however, how B cells are instructed to generate high-affinity IgE. Gowthaman et al. discovered a subset of T follicular helper cells (T FH 13) that direct B cells to do just that. T FH 13 cells are induced by allergens but not during parasite infection. Transgenic mice lacking these cells show impaired production of high-affinity, anaphylactic IgE. T FH 13 cells, which are elevated in patients with food and aeroallergies, may be targeted in future antianaphylaxis therapies. Science , this issue p. eaaw6433

Funder

National Institutes of Health

Food Allergy Research and Education

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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