A phenotypically and functionally distinct human T H 2 cell subpopulation is associated with allergic disorders-Reference-Cited by-同舟云学术

A phenotypically and functionally distinct human T H 2 cell subpopulation is associated with allergic disorders

Published:2017-08-02 Issue:401 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wambre Erik¹^ORCID,Bajzik Veronique¹^ORCID,DeLong Jonathan H.¹^ORCID,O’Brien Kimberly¹^ORCID,Nguyen Quynh-Anh¹^ORCID,Speake Cate¹^ORCID,Gersuk Vivian H.¹^ORCID,DeBerg Hannah A.¹^ORCID,Whalen Elizabeth¹^ORCID,Ni Chester¹^ORCID,Farrington Mary²^ORCID,Jeong David²^ORCID,Robinson David²^ORCID,Linsley Peter S.¹^ORCID,Vickery Brian P.³,Kwok William W.¹⁴^ORCID

Affiliation:

1. Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

2. Virginia Mason Medical Center, Seattle, WA 98101, USA.

3. Aimmune Therapeutics, Brisbane, CA 94005, USA.

4. Department of Immunology, University of Washington, Seattle, WA 98195, USA.

Abstract

A unique T helper cell signature in allergic patients isolates the pathogenic cells and provides a target for disease intervention.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. T-cell responses in allergy and asthma

2. Hierarchical IL-5 Expression Defines a Subpopulation of Highly Differentiated Human Th2 Cells

3. TH2 heterogeneity: Does function follow form?

4. The Role of IFN-γ in the Production of Th2 Subpopulations: Implications for Variable Th2-Mediated Pathologies in Autoimmunity

5. Identification of a novel subset of human circulating memory CD4+ T cells that produce both IL-17A and IL-4

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