Exosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-47494-w.pdf
Reference44 articles.
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2. Glasson, S. S. et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 434, 644–648 (2005).
3. Stanton, H. et al. ADAMTS-5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434, 648–652 (2005).
4. El Bakali, J. et al. Inhibition of aggrecanases as a therapeutic strategy in osteoarthritis. Future Med Chem. 6, 1399–1412 (2014).
5. Santamaria, S. & de Groot, R. Monoclonal antibodies against metzincin targets. Br J Pharmacol 176, 52–66 (2019).
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