Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors

Published:2024 Issue:8 Volume:15 Page:2806-2825
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Cuffaro Doretta¹^ORCID,Burkhard Tina²^ORCID,Bernardoni Bianca Laura¹^ORCID,Di Leo Riccardo¹^ORCID,Zhang Xiaohan³,Galati Salvatore¹^ORCID,Tuccinardi Tiziano¹,Macchia Marco¹,Rossello Armando¹,Santamaria Salvatore²^ORCID,de Groot Rens³^ORCID,Nuti Elisa¹^ORCID

Affiliation:

1. Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy

2. Department of Biochemical and Physiological Sciences, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Edward Jenner Building, Guildford GU2 7XH, UK

3. Institute of Cardiovascular Science, University College London, 51 Chenies Mews, London WC1E 6HX, UK

Abstract

Starting from the ADAMTS5/ADAMTS7 inhibitor EDV33, a structure-based optimization led to the lead compound 3a, with nanomolar activity against ADAMTS7 and good selectivity over ADAMTS5.

Funder

British Heart Foundation

Università di Pisa

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00149D

Reference49 articles.

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4. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

5. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease