Metabolism of a G Protein-Coupled Receptor Modulator, Including Two Major 1,2,4-Oxadiazole Ring-Opened Metabolites and a Rearranged Cysteine-Piperazine Adduct-Reference-Cited by-同舟云学术

Metabolism of a G Protein-Coupled Receptor Modulator, Including Two Major 1,2,4-Oxadiazole Ring-Opened Metabolites and a Rearranged Cysteine-Piperazine Adduct

Published:2012-03-07 Issue:6 Volume:40 Page:1151-1163
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Gu Chungang,Elmore Charles S.,Lin Jianrong,Zhou Diansong,Luzietti Rick,Dorff Peter,Grimm Scott W.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference26 articles.

1. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: A rationale for long-lived plasma radioactivity

2. Approaches to the Assessment of Stable and Chemically Reactive Drug Metabolites in Early Clinical Trials

3. Interspeciesin vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560

4. Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

5. Addressing Metabolic Activation as an Integral Component of Drug Design

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure;Journal of Medicinal Chemistry;2024-05-29

2. Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies;Drug Metabolism and Pharmacokinetics;2022-08

3. Absorption, metabolism and excretion of opicapone in human healthy volunteers;British Journal of Clinical Pharmacology;2022-05-20

4. 1,2,4-Oxadiazoles;Comprehensive Heterocyclic Chemistry IV;2022

5. Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping;Pharmacology Research & Perspectives;2021-12-22