The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates-Reference-Cited by-同舟云学术

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The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates

Published:2016-09-02 Issue:11 Volume:44 Page:1819-1827
ISSN:1521-009X
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metabolism and Disposition

Author:

Rougee L. R. A.,Mohutsky M. A.,Bedwell D. W.,Ruterbories K. J.,Hall S. D.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference47 articles.

1. The antitussive effect of dextromethorphan in relation to CYP2D6 activity

2. Pharmacokinetics of amiodarone after intravenous and oral administration

3. The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation

4. Consistency of the Novel Equations for Determination of Hepatic Clearance and Drug Time Course in Liver that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water

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1. Pharmacokinetic Models Scaled Up from Humanized Liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated andN-Demethylated Metabolites in Pediatric Patients Genotyped for CytochromeP450 2D6;Drug Metabolism and Disposition;2023-10-25

2. The Computational Acid–Base Chemistry of Hepatic Ketoacidosis;Metabolites;2023-06-28

3. Hidden chronic metabolic acidosis of diabetes type 2 (CMAD): Clues, causes and consequences;Reviews in Endocrine and Metabolic Disorders;2023-06-28

4. Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review;Drug Metabolism Reviews;2023-04-12

5. Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan;Frontiers in Pharmacology;2022-10-24

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