Pharmacokinetic Models Scaled Up from Humanized Liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated andN-Demethylated Metabolites in Pediatric Patients Genotyped for CytochromeP450 2D6-Reference-Cited by-同舟云学术

Pharmacokinetic Models Scaled Up from Humanized Liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated andN-Demethylated Metabolites in Pediatric Patients Genotyped for CytochromeP450 2D6

Published:2023-10-25 Issue:1 Volume:52 Page:35-43
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Shimizu Makiko^ORCID,Uehara Shotaro,Ohyama Katsuhiro,Nishimura Haruka,Tanaka Yoichi^ORCID,Saito Yoshiro,Suemizu Hiroshi,Yoshida Sayaka,Yamazaki Hiroshi^ORCID

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference40 articles.

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2. High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database;Adachi;Drug Metab Pharmacokinet,2023

3. Modeled rat hepatic and plasma concentrations of chemicals after virtual administrations using two sets of in silico liver-to-plasma partition coefficients;Adachi;Biol Pharm Bull,2023

4. The development of a PBPK model for atomoxetine using levels in plasma, saliva and brain extracellular fluid in patients with normal and deteriorated kidney function;Alsmadi;CNS Neurol Disord Drug Targets,2022

5. Apparent Mechanism-based Inhibition of Human CYP2D6 in Vitro by Paroxetine: Comparison with Fluoxetine and Quinidine

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1. Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database;Biological and Pharmaceutical Bulletin;2024-05-24

2. Modeled Hepatic/Plasma Exposures of Fluvastatin Prescribed Alone in Subjects with Impaired Cytochrome P450 2C9*3 as One of Possible Determinant Factors Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database;Biological and Pharmaceutical Bulletin;2024-03-15