The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation-Reference-Cited by-同舟云学术

The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation

Published:2011-03 Issue:3 Volume:100 Page:1167-1183
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Berezhkovskiy Leonid M.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference67 articles.

1. A dispersion model of hepatic elimination: 2. Steady-state considerations–influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity;Roberts;Pharmacokinet Biopharm,1986

2. Factors affecting drug metabolism;Gillette;Ann NY Acad Sci,1971

3. Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions;Rodgers;J Pharm Sci,2006

4. On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay;Berezhkovskiy;J Pharm Sci,2009

5. A Valid Equation for the Well-Stirred Perfusion Limited Physiologically Based Pharmacokinetic Model that Consistently Accounts for the Blood–Tissue Drug Distribution in the Organ and the Corresponding Valid Equation for the Steady State Volume of Distribution

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