Investigations into the Mechanisms of Pyridine Ring Cleavage in Vismodegib-Reference-Cited by-同舟云学术

Investigations into the Mechanisms of Pyridine Ring Cleavage in Vismodegib

Published:2014-01-03 Issue:3 Volume:42 Page:343-351
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Khojasteh S. Cyrus,Yue Qin,Ma Shuguang,Castanedo Georgette,Chen Jacob Z,Lyssikatos Joseph,Mulder Teresa,Takahashi Ryan,Ly Justin,Messick Kirsten,Jia Wei,Liu Lichuan,Hop Cornelis E. C. A.,Wong Harvey

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference23 articles.

1. Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

2. The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity

3. N-Methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosy1-L-methioninedependent reaction

4. Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449)

5. Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

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