Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449)-Reference-Cited by-同舟云学术

Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449)

Published:2011-03-25 Issue:8 Volume:54 Page:2592-2601
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Giannetti Anthony M.¹,Wong Harvey¹,Dijkgraaf Gerrit J. P.¹,Dueber Erin C.¹,Ortwine Daniel F.¹,Bravo Brandon J.¹,Gould Stephen E.¹,Plise Emile G.¹,Lum Bert L.¹,Malhi Vikram¹,Graham Richard A.¹

Affiliation:

1. Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1008924

Reference34 articles.

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4. Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

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