Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain-Reference-Cited by-同舟云学术

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain

Published:2017-05-12 Issue:13 Volume:60 Page:5349-5363
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Denny R. Aldrin¹^ORCID,Flick Andrew C.²,Coe Jotham²,Langille Jonathan,Basak Arindrajit²,Liu Shenping³,Stock Ingrid⁴,Sahasrabudhe Parag³,Bonin Paul⁴,Hay Duncan A.⁵⁶,Brennan Paul E.⁶,Pletcher Mathew⁷,Jones Lyn H.¹^ORCID,Chekler Eugene L. Piatnitski¹

Affiliation:

1. Medicine Design, Pfizer, 610 Main Street, Cambridge Massachusetts 02139, United States

2. Medicine Design, Pfizer, Eastern Point Road, Groton Connecticut 06340, United States

3. Structural Biology and Biophysics, Medicine Design, Pfizer, Eastern Point Road, Groton Connecticut 06340, United States

4. Primary Pharmacology Group, Pfizer, Eastern Point Road, Groton Connecticut 06340, United States

5. Evotec (UK) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK

6. Structural Genomics Consortium, Target Discovery Institute, ARUK Oxford Drug Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford OX3 7FZ, U.K.

7. Rare Disease Research Unit, Pfizer, 610 Main Street, Cambridge Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01839

Reference44 articles.

1. Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions

2. Place your BETs: the therapeutic potential of bromodomains

3. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

4. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

5. Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300

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