Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)-Reference-Cited by-同舟云学术

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

Published:2016-03-25 Issue:5 Volume:7 Page:531-536
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Taylor Alexander M.¹,Côté Alexandre¹,Hewitt Michael C.¹,Pastor Richard²,Leblanc Yves¹,Nasveschuk Christopher G.¹,Romero F. Anthony²,Crawford Terry D.²,Cantone Nico¹,Jayaram Hariharan¹,Setser Jeremy¹,Murray Jeremy²,Beresini Maureen H.²,de Leon Boenig Gladys²,Chen Zhongguo³,Conery Andrew R.¹,Cummings Richard T.¹,Dakin Leslie A.¹,Flynn E. Megan²,Huang Oscar W.²,Kaufman Susan²,Keller Patricia J.¹,Kiefer James R.²,Lai Tommy³,Li Yingjie³,Liao Jiangpeng³,Liu Wenfeng³,Lu Henry³,Pardo Eneida¹,Tsui Vickie²,Wang Jian³,Wang Yongyun³,Xu Zhaowu³,Yan Fen³,Yu Dong³,Zawadzke Laura¹,Zhu Xiaoqin³,Zhu Xiaoyu³,Sims Robert J.¹,Cochran Andrea G.²,Bellon Steve¹,Audia James E.¹,Magnuson Steven²,Albrecht Brian K.¹

Affiliation:

1. Constellation Pharmaceuticals, 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States

2. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

3. Wuxi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People’s Republic of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00075

Reference31 articles.

1. Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors