Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300-Reference-Cited by-同舟云学术

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300

Published:2016-09-28 Issue:23 Volume:59 Page:10549-10563
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Crawford Terry D.¹,Romero F. Anthony¹,Lai Kwong Wah²,Tsui Vickie¹,Taylor Alexander M.³,de Leon Boenig Gladys¹,Noland Cameron L.¹,Murray Jeremy¹,Ly Justin¹,Choo Edna F.¹,Hunsaker Thomas L.¹,Chan Emily W.¹,Merchant Mark¹,Kharbanda Samir¹,Gascoigne Karen E.¹,Kaufman Susan¹,Beresini Maureen H.¹,Liao Jiangpeng²,Liu Wenfeng²,Chen Kevin X.²,Chen Zhongguo²,Conery Andrew R.³,Côté Alexandre³,Jayaram Hariharan³,Jiang Ying²,Kiefer James R.¹,Kleinheinz Tracy¹,Li Yingjie²,Maher Jonathan¹,Pardo Eneida³,Poy Florence³,Spillane Kerry L.³,Wang Fei²,Wang Jian²,Wei Xiaocang²,Xu Zhaowu²,Xu Zhongya²,Yen Ivana¹,Zawadzke Laura³,Zhu Xiaoyu²,Bellon Steven³,Cummings Richard³,Cochran Andrea G.¹,Albrecht Brian K.³,Magnuson Steven¹

Affiliation:

1. Genentech, Inc. 1 DNA Way, South San Francisco, California 94080, United States

2. Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People’s Republic of China

3. Constellation Pharmaceuticals, Inc. 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01022

Reference27 articles.

1. Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors