Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry

Author:

Furukawa Akihiro12,Townsend Chad E.1,Schwochert Joshua1,Pye Cameron R.1,Bednarek Maria A.3,Lokey R. Scott1

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States

2. Modality Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

3. Department of Antibody Discovery & Protein Engineering, Medimmune Ltd., Cambridge CB21 6GH, United Kingdom

Funder

Daiichi Sankyo Company

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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