Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry-Reference-Cited by-同舟云学术

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Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry

Published:2016-10-11 Issue:20 Volume:59 Page:9503-9512
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Furukawa Akihiro¹²,Townsend Chad E.¹,Schwochert Joshua¹,Pye Cameron R.¹,Bednarek Maria A.³,Lokey R. Scott¹

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States

2. Modality Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

3. Department of Antibody Discovery & Protein Engineering, Medimmune Ltd., Cambridge CB21 6GH, United Kingdom

Funder

Daiichi Sankyo Company

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01246

Reference40 articles.

1. Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

2. Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

3. Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

4. On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

5. Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

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