An <i>N-ortho</i>-nitrobenzylated benzanilide amino acid enables control of the conformation and membrane permeability of cyclic peptides-Reference-Cited by-同舟云学术

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An N-ortho-nitrobenzylated benzanilide amino acid enables control of the conformation and membrane permeability of cyclic peptides

Published:2024 Issue:69 Volume:60 Page:9242-9245
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Otani Yuko¹^ORCID,Ichinose Asami¹,Wang Xihong¹,Huang Zhihan¹,Kasahara Akitomo¹,Ishii Mayumi¹,Watanabe Eri¹,Kanamitsu Kayoko¹,Tai Kempei¹,Kusuhara Hiroyuki¹,Ueda Takumi¹²^ORCID,Takeuchi Koh¹^ORCID,Ohwada Tomohiko¹^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

2. Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamadaoka, Suita-Shi, Osaka, Japan

Abstract

We designed and synthesized an N-ortho-nitrobenzylated benzanilide-based amino acid having a cis-amide structure that facilitates cyclization of peptides containing it.

Funder

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC02738H

Reference23 articles.

1. Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor

2. Inhibition of Ras Signaling by Blocking Ras-Effector Interactions with Cyclic Peptides

3. Crystal Structures of Protein-Bound Cyclic Peptides

4. Strategies for Fine-Tuning the Conformations of Cyclic Peptides

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