Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation-Reference-Cited by-同舟云学术

Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation

Published:2024-02-08 Issue:7 Volume:146 Page:4582-4591
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Faris Justin H.¹,Adaligil Emel²,Popovych Nataliya³,Ono Satoshi⁴^ORCID,Takahashi Mifune⁵,Nguyen Huy⁶,Plise Emile⁵,Taechalertpaisarn Jaru¹^ORCID,Lee Hsiau-Wei¹,Koehler Michael F. T.⁷,Cunningham Christian N.²^ORCID,Lokey R. Scott¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States

2. Department of Peptide Therapeutics, Genentech, South San Francisco, California 94080, United States

3. Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, United States

4. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kanagawa 227-0033, Japan

5. Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California 94080, United States

6. Department of Analytical Research, Genentech, South San Francisco, California 94080, United States

7. Department of Medicinal Chemistry, Genentech, South San Francisco, California 94080, United States

Funder

Division of Chemistry

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c10949

Reference73 articles.

1. Drugging the 'undruggable' cancer targets

2. Strategies for targeting undruggable targets

3. Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL

4. MOrPH-PhD: An Integrated Phage Display Platform for the Discovery of Functional Genetically Encoded Peptide Macrocycles

5. High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Influence of Disulfide, Thioacetal and Lanthionine‐Bridges on the Conformation of a Macrocyclic Peptide;Chemistry – A European Journal;2024-08-20

2. Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides;Chemical Communications;2024