Oxidation-guided and collision-induced linearization assists <i>de novo</i> sequencing of thioether macrocyclic peptides-Reference-Cited by-同舟云学术

Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides

Published:2024 Issue:70 Volume:60 Page:9436-9439
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hayashi Ayaka¹,Goto Yuki²³⁴^ORCID,Saito Yutaro⁵^ORCID,Suga Hiroaki²^ORCID,Morimoto Jumpei⁵^ORCID,Sando Shinsuke¹⁵^ORCID

Affiliation:

1. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

2. Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

3. Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan

4. Toyota Riken Rising Fellow, Toyota Physical and Chemical Research Institute, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan

5. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan

Abstract

Oxidized thioether-closed macrocyclic peptides are site-selectively linearized upon collision-induced fragmentation, which enhances sequence deconvolution of cyclic peptides.

Funder

Core Research for Evolutional Science and Technology

Japan Society for the Promotion of Science

Precursory Research for Embryonic Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC03179B

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4. Cyclic Peptidyl Inhibitors of Grb2 and Tensin SH2 Domains Identified from Combinatorial Libraries