HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites-Reference-Cited by-同舟云学术

HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites

Published:2021-11-04 Issue:22 Volume:64 Page:16530-16540
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Losada Natalie¹²,Ruiz Francesc X.¹²,Curreli Francesca³,Gruber Kevin¹²,Pilch Alyssa¹,Das Kalyan¹^ORCID,Debnath Asim K.³^ORCID,Arnold Eddy¹²^ORCID

Affiliation:

1. Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, United States

2. Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States

3. Laboratory of Molecular Modeling & Drug Design, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York 10065, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01104

Reference35 articles.

1. HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

2. Bifunctional Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Mechanism and Proof-of-Concept as a Novel Therapeutic Design Strategy

3. Identification of novel bifunctional HIV-1 reverse transcriptase inhibitors

4. Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors

5. Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Deciphering the enigmas of non‐nucleoside reverse transcriptase inhibitors (NNRTIs): A medicinal chemistry expedition towards combating HIV drug resistance;Medicinal Research Reviews;2024-08-26

2. Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists;International Journal of Molecular Sciences;2022-12-15

3. Comparative Pharmacokinetics of a Dual Inhibitor of HIV-1, NBD-14189, in Rats and Dogs with a Proof-of-Concept Evaluation of Antiviral Potency in SCID-hu Mouse Model;Viruses;2022-10-16

4. Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors;Journal of Medicinal Chemistry;2022-02-17

5. Recent research results have converted gp120 binders to a therapeutic option for the treatment of HIV-1 infection. A medicinal chemistry point of view;European Journal of Medicinal Chemistry;2022-02