Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy-Reference-Cited by-同舟云学术

Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy

Published:2018-02-12 Issue:4 Volume:61 Page:1704-1718
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Banerjee Souvik¹,Arnst Kinsie E.¹,Wang Yuxi²,Kumar Gyanendra³,Deng Shanshan¹,Yang Lei⁴,Li Guo-bo²^ORCID,Yang Jinliang²,White Stephen W.³,Li Wei¹^ORCID,Miller Duane D.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States

2. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China

3. Structural Biology Department, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

4. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, United States

Funder

National Cancer Institute

American Lebanese Syrian Associated Charities, St. Jude Children?s Research Hospital

Drug Discovery Center, University of Tennessee

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01858