First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity-Reference-Cited by-同舟云学术

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity

Published:2015-05-13 Issue:11 Volume:58 Page:4822-4838
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Eng Wai Soon¹,Hocková Dana²,Špaček Petr²,Janeba Zlatko²,West Nicholas P.¹,Woods Kyra¹,Naesens Lieve M. J.³,Keough Dianne T.¹,Guddat Luke W.¹

Affiliation:

1. The School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 QLD Australia

2. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i. Flemingovo nam. 2, CZ-166 10 Prague 6, Czech Republic

3. Rega Institute for Medical Research, KU Leuven − University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Funder

Gilead Sciences

National Health and Medical Research Council

Czech Science Foundation

Ústav organické chemie a biochemie AV CR

Ministerstvo vnitra Ceské republiky

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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